Bioprexum Plus Dosage/Direction for Use

1 tab/day as a single dose, preferably to be taken in the morning and before a meal.
When possible, individual dose titration with the components is recommended.
Elderly: Treatment should be initiated after considering blood pressure response and renal function (see Precautions).
Renal Impairment: In severe renal impairment (CrCl <30 mL/min), treatment is contraindicated (see Contraindications).
In patients with moderate renal impairment (CrCl 30-60 mL/min), it is recommended to start treatment with the adequate dosage of the free combination (see Precautions).
In patients with CrCl ≥60 mL/min, no dose modification is required. Usual medical follow-up will include frequent monitoring of creatinine and potassium.
Hepatic Impairment: In severe hepatic impairment, treatment is contraindicated (see Contraindications).
In patients with moderate hepatic impairment, no dose modification is required (see Pharmacokinetics under Actions and Precautions).
Children and Adolescents: Bioprexum Plus should not be used in children and adolescents as the efficacy and tolerability of perindopril in children and adolescents, alone or in combination, have not been established.